Gene Designing

‘Cause we are crazy bio guys, Come on show ‘em parts you did, Make ‘em go “oh,oh” As you make it fancy-y-y.

— We iGEMers song modified from Fireworks, by Shunzhe Ma.

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Research Summary

Cardiovascular disease (CVD) is the No. 1 killer of human beings. On average, there are about 17.5 million people dying from CVD each year, which accounts for 31% of all deaths of human beings on Earth. One of the priorities of the WHO program on Cardiovascular Diseases is the development of “cost effective and equitable health care innovations”. The health care for cardiovascular diseases includes various drugs, and tanshinone is one of the most important ingredients in multiple medicines for cardiovascular diseases. One of the enzymes in tanshinone called SmCPS1 plays the key rule in treating the cardiovascular diseases.

SmCPS1 can act as an inhibitor of angiotensin converting enzyme (ACE), hence leading to a decrease in blood pressure and blood clotting, as well as a dilation of arteries
(Adams et al., 2006). An isomer of tanshinone, tanshinone II A, has been demonstrated to prevent atherogenesis, cardiac injuries, and hypertrophy (Gao et al., 2012). Now, Salvia miltiorrhiza and the tanshinone extracted from it are clinically used for the prevention and treatment of cardiovascular diseases (e.g. coronary heart diseases) (Luo et al, 2015).

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